|
KMID : 0385020000160030213
|
|
Korean Journal of Laboratory Animal Science
2000 Volume.16 No. 3 p.213 ~ p.220
|
|
|
Age-related Decline of Cerebral ATP and Choline Content in Senscence-accelerated Mouse Prone 8(SAM P8)
|
|
Han, sang seop
Jung, Kyu Yong/Choi, Bong Kyu
|
|
|
Abstract
|
|
|
|
Senescence-accelerated mouse prone 8 (SAM P8) is known as a model mice exhibiting deteriorated learning and memory ability. We examined the changes of cerebral adenosine triphosphate (ATP) and choline content associated with learning and memory impairments in SAM P8. The intracellular ATP and choline content of cerebral cortex in 36-week-old SAM P8 were significantly lower than that of age-matched senescence-resistant prone 1 (SAM R1) as a control mice (p$lt;0.05 and p$lt;0.01, respectively), but such a difference between these two strains was not observed in 16-week old mice. Additionally, the activity of protein carboxyl O-methyltransferase in the cerebral cortex of SAM P8 aged 36 weeks was significantly higher than that of age-matched SAM R1 (3.4-fold, p$lt;0.001), but no difference of enzyme activity between these two strains was observed in 16-week-old mice. Taken together, these results suggest that the aging process in the cerebral cortex of SAM P8 is accompanied by alteration for maintenance of intracellular ATP and choline homeostasis, and this may be associated with pathological change of overall mechanisms involved in the development of neuronal diseases, including learning and memory deficiency, in SAM P8.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|